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Effect of the combination of ZLDI‐8 with 5‐FU/irinotecan on the Notch pathway. A, Protein level of ADAM17 in LoVo cells was assayed by Western blot. B, Western blot was used to analyse expression of N1‐4ICD and Hes1 when treatment with ZLDI‐8, 5‐FU/irinotecan, alone or combination. β‐actin was used as a loading control. (C,D), Bar graphs showed the quantitative results of ADAM17, N1‐4ICD and Hes1. *P < .05 vs control, # P < .05 vs 5‐FU or irinotecan. Irinotecan (irino)
