Figure 7.

ZLDI‐8 and 5‐FU synergistically inhibited the growth of CRC in xenograft models. A, Schematic diagram of the xenograft model in this study. ZLDI‐8 was suspended in 5‰ CMCNa, 5‐FU was dissolved in normal saline. control (CMCNa,qd×25, Po;normal saline, q4d×25, ip); ZLDI‐8 (qd×25, Po, 80 mg/kg); 5‐FU (q4d×25, ip 30 mg/kg); ZLDI‐8 (qd×25, Po, 80 mg/kg) and 5‐FU (q4d×25, ip 30 mg/kg). B, Tumour volume was measured every other day. (C,D), Tumour weight and imaging of representative tumours from each group were shown at the end of the experiment. E, Tumour lysate come from 3 mice. Noth signalling and EMT markers were analysed by Western blot assay. *P < .05, ***P < .001 vs control