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. 2017 Nov 30;51(1):e12409. doi: 10.1111/cpr.12409

Figure 6.

Figure 6

Cancer susceptibility candidate 2 (CASC2) suppressed the osteosarcoma cell proliferation, colony formation and invasion through regulating Ras association domain family member 6 (RASSF6) expression. A, The expression of RASSF6 in the MG‐63 cell transfected with si‐RASSF6 was determined by qRT‐PCR. B, The protein expression of RASSF6 was measured by Western blot. C, Knockdown of RASSF6 promoted the CASC2 overexpressing MG‐63 cell proliferation. D, Downregulation of RASSF6 enhanced the CASC2‐overexpressing MG‐63 cell colony formation. The relative colony numbers were shown. E, Downregulation of RASSF6 enhanced the CASC2‐overexpressing MG‐63 cell invasion. Relative ratio of invasive cells per field is shown. *P < .05, **P < .01 and ***P < .001