Figure 5.

In vivo development of re‐aggregated Ep‐Me cells from p4 at secretory stage in mouse subrenal capsule. (A), The re‐associated explants with epithelial and mesenchymal cell compartmentalization (E70 Ep‐Me) restore the de novo odontogenesis at 8 wk post‐transplantation. Top panel: macro view of regenerated tissues (red dotted line). Bottom panels: histological analysis (H&E staining). (B), The re‐associated explants with epithelial and mesenchymal cell compartmentalization (E70 Ep‐Me) developed into tooth‐like structures (red dotted line) after transplantation for 16 wk in the subrenal capsule, viewed by X‐rays and H&E staining. b, bone; d, dentin; dp, dental pulp. Scale bars: gross view, 1 mm; histology, 100 μm