Figure 7.

The potential targets of B7 family members predicted by cBioportal. (A) B7‐1 and B7‐2 showed highly combined interaction to other gene signalling, while B7‐H1 and B7‐DC demonstrated limited combined interaction to other gene singling. (B) Phylogenetic analysis of B7 family members and their potential targets. Neighbour‐joining tree was constructed with Mega7 program. Red colour represents known B7 receptors. Many potential B7 targets from the network analysis were very closely related to known B7 receptors. (C) Domain analysis of B7 family reacting proteins. The SH2, SH3 and Pkinase domain existed in most potential B7 interacting proteins. The B7‐H1/DC potential target CD4 has the V‐set domain which is similar to the known CD28 family, indicating it might be a novel B7 receptor