Figure 8.

DTPEP and TAM induces apoptosis in mammary tumour tissue of LA‐7 rat mammary tumour model. The fragmented DNA indicative of apoptotic cells were visualized with TUNEL stain using 60× magnification of confocal microscope (FV1200 Multi Photon Laser Scanning Microscope; Olympus, Tokyo, Japan). DTPEP and tamoxifen reverses aggressively proliferating malignant cellular histomorphology of rat mammary tumour (H & E). DTPEP and tamoxifen downregulates expression of ERα and PKCα in rat mammary tumour (IHC). Images were captured at 20× magnification of CKX41 Trinocular with cooled CCD camera Model Imaging MP5.0‐RTV‐CLR‐10‐c from Olympus