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. 2017 Jun 15;50(4):e12352. doi: 10.1111/cpr.12352

Figure 5.

Figure 5

Histological tumour‐derived analysis. The B16F10 cells and the MMRC were subcutaneously transplanted into dorsal flanks of mice (C57Bl6). After twenty days, the animals were euthanized and the tumours were collected at the same day. In (A) comparison of the size tumours derived from MMRC and B16F10 parental cell line. (B) Haematoxylin and eosin staining of tumour derived from MMRC clones and B16F10 cell line. Compared to B16F10, the MMRC tumour‐derived histological analysis suggests lower tumourigenicity, reduced tissue necrosis and decreased cell heterogeneity