Figure 4.

Experimentally proved lncRNAs involving OA. Apoptosis, ECM degradation, angiogenesis and inflammatory response are known to promote the development of OA. HOTAIR and GAS5 can induce chondrocyte cell apoptosis, and PCGEM1 increases the apoptotic rate of synoviocytes. HOTTIP, lncRNA‐CIR, HOTAIR and GAS5 stimulate but H19 inhibits cartilage ECM degradation. MEG3 antagonizes angiogenesis within the articular cartilage. Additionally, both CILinc01 and CILinc02 suppress inflammatory response. Red arrows indicate upregulation, and green arrows represent downregulation