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. 2016 Dec 2;50(3):e12320. doi: 10.1111/cpr.12320

Figure 2.

Figure 2

Neutralising serum amyloid A (SAA) alleviates epidermal hyperplasia in imiquimod (IMQ)‐induced mice. IMQ‐induced mice were treated with neutralising anti‐SAA antibody or control IgG. A, Representative clinical pictures (top) and H&E staining (bottom) are shown on skin sections of BALB/c mice treated with topical Vaseline and ip injection of anti‐SAA antibody (n=6), topical Vaseline and ip control IgG (n=6), topical IMQ and ip anti‐SAA antibody (n=6), or topical IMQ and ip control IgG (n=6) at day 14 of treatment. Scale bar=50 μm. B, Epidermal thickness and (C) infiltrated cells in dermis were measured in back skin from the anti‐SAA antibody or control IgG‐treated mice. D, IL‐17A and (E) CCL20 mRNA expression was detected by real‐time PCR. For B‐E, each point represents a skin sample obtained from a mouse. The data represent one of three independent experiments (*P<.05, **P<.01, one‐way ANOVA)