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Schematic model for ADIPO CM regulation on the osteoclast differentiation and activation. Adipocytes secrete CXCL12 into extracellular environment. Then, the extracellular CXCL12 binds to its receptor CXCR4 expressed on the preosteoclasts, further to enhance the differentiation, and activity of osteoclasts as well as the expression of osteoclast adhesion‐related molecules such as β3 integrin, CD44 and OPN
