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. 2019 May 16;11:4505–4518. doi: 10.2147/CMAR.S196025

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© 2019 Cao et al.

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HOXA11-AS promotes the invasion and migration of OS through competitive binding with miR-125a-5p. (A, E) Inhibition of miR-125-5p expression could counteract the ability of HOXA11-AS- siRNAs to inhibit cell migration (*P<0.05, **P<0.01). (B, G) Up-regulation of miR-125-5p expression could inhibit the promoting effect of HOXA11-AS overexpression on migration of KHOS cells (*P<0.05, **P<0.01). (C, F) Inhibition of miR-125-5p expression could counteract the ability of HOXA11-AS- siRNAs to inhibit cell invasion (*P<0.05, **P<0.01). (D, H) Up-regulation of miR-125-5p expression could inhibit the promoting effect of HOXA11-AS overexpression on invasion of KHOS cells (**P<0.01).