Table 2:
Characteristics of people with cirrhosis or hepatocellular carcinoma.
| Characteristics | HCC cases (N=312) N (%) |
Cirrhosis cases (N=119) N (%) |
p value |
|---|---|---|---|
| Age, years | 0.05 | ||
| < 35 | 65 (20.8) | 36 (30.2) | |
| 35 - 49 | 101 (32.4) | 44 (37.0) | |
| 50 - 59 | 65 (20.8) | 17 (14.3) | |
| ≥ 60 | 81 (26.0) | 22 (18.5) | |
| Sex | 0.001 | ||
| Males | 251 (80.5) | 78 (65.6) | |
| Females | 61 (19.5) | 41 (34.4) | |
| Study site | 0.11 | ||
| RVH | 124 (39.7) | 58 (48.7) | |
| MRC | 98 (31.4) | 26 (21.9) | |
| BSG | 90 (28.9) | 26 (29.4) | |
| Ethnic group | 0.60 | ||
| Madinka | 83 (26.6) | 28 (23.5) | |
| Fula | 78 (25.0) | 36 (30.3) | |
| Wollof | 65 (20.8) | 27 (22.7) | |
| Others/unknown | 86 (27.6) | 28 (23.5) | |
| Attended school | 0.98 | ||
| Never | 66 (21.2) | 25 (21.0) | |
| Ever | 240 (76.9) | 92 (77.3) | |
| Unknown | 6 (1.9) | 2 (1.7) | |
| Earth floor house | 0.55 | ||
| No | 126 (40.4) | 43 (36.1) | |
| Yes | 177 (56.7) | 74 (62.2) | |
| Unknown | 9 (2.9) | 2 (1.7) | |
| Alcohol intake | 0.48 | ||
| Never | 260 (83.3) | 104 (87.4) | |
| Ever | 40 (12.8) | 10 (8.4) | |
| Unknown | 12 (3.9) | 5 (4.2) | |
| Cigarette smoking | 0.06 | ||
| Never smoker | 136 (43.6) | 69 (58.0) | |
| Former smoker | 110 (35.3) | 32 (26.9) | |
| Current smoker | 54 (17.3) | 16 (13.5) | |
| Unknown | 12 (3.9) | 2 (1.7) | |
| Family history of cancer | 0.66 | ||
| No | 276 (88.5) | 109 (91.6) | |
| Yes | 30 (9.6) | 8 (6.7) | |
| Unknown | 6 (1.9) | 2 (1.7) | |
| Marital status | 0.45 | ||
| Never married | 34 (10.9) | 18 (15.1) | |
| Ever married | 272 (87.2) | 99 (83.2) | |
| Unknown | 6 (1.9) | 2 (1.7) | |
| Body mass index, kg/m2 | < 0.001 | ||
| < 18.5 | 111 (35.6) | 20 (16.8) | |
| ≥ 18.5 | 82 (26.3) | 62 (52.1) | |
| Unknown | 119 (38.1) | 37 (31.1) | |
| anti-HCV | |||
| Negative | 230 (73.7) | 99 (83.2) | 0.04 |
| Positive | 46 (14.7) | 7 (5.9) | |
| Unknown | 36 (11.5) | 13 (10.9) | |
| Ser-249 TP53 mutation | < 0.001 | ||
| Absent | 98 (31.4) | 84 (70.6) | |
| Present | 66 (21.2) | 15 (12.6) | |
| Unknown | 148 (47.4) | 20 (16.8) | |
| HDV status (based on HDV RNA positivity) | 0.65 | ||
| HBsAg− / HDV RNA− | 129 (41.4) | 52 (43.7) | |
| HBsAg+ / HDV RNA− | 172 (55.1) | 61 (51.3) | |
| HBsAg+ / HDV RNA+ | 11 (3.5) | 6 (5.0) | |
| HDV status (based on anti-HDV positivity) | 0.66 | ||
| HBsAg− / anti-HDV− | 129 (41.4) | 52 (43.7) | |
| HBsAg+ / anti-HDV− | 165 (52.9) | 58 (48.7) | |
| HBsAg+ / anti-HDV+ | 18 (5.8) | 9 (7.6) |
Abbreviations: HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; HDV, hepatitis D virus; RVH, Royal Victoria Hospital, Banjul; MRC, Medical Research Council Hospital, Fajara; BSG, Bansang Hospital, Bansang