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. 2018 Oct 31;25(4):359–379. doi: 10.1177/1073858418807887

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Box 3 Figure. — Synaptic plasticity. Pre- and postsynaptic signaling cascades responsible for long-term potentiation/depression (LTP/LTD). Abbreviations: MEK-ERK, mitogen-activated protein kinase kinase (MEK)–extracellular signal-regulated kinase (ERK); AKT, protein kinase B; PLC, phospholipase C; PI3K, phosphoinositide 3-kinase; CICR, calcium-induced calcium release; PLD, phospholipase D; eCB, endocannabinoid; µ/δOR, µ/δ opioid receptor; 5-HT1bR, 5-HT type 1b receptor; other abbreviations as in text.