Table 2.

Adipokine distributions across pregnancy overall and according to maternal pre-pregnancy obesity status.

		Pre-Pregnancy BMI
	Overall (n=321)	< 30.0 kg/m2 (n=255)	≥ 30.0 kg/m2 (n=66)
	Median (IQR)	Median (IQR)	Median (IQR)	Pa
Leptin, ng/ml
10–14 weeks	30.7 (20.3, 48.6)	27.6 (19.6, 43.6)	65.6 (46.1, 79.1)	<0.001
15–26 weeks	38.8 (26.9, 53.5)	34.6 (25.4, 46.8)	71.8 (57.3, 86.3)	<0.001
23–31 weeks	40.6 (27.5, 59.1)	38.6 (26.1, 52.5)	78.2 (59.1, 93.7)	<0.001
33–39 weeks	40.4 (26.2, 67.5)	35.4 (24.3, 57.9)	79.7 (53.1, 93.2)	<0.001
sOB-R, ng/ml
10–14 weeks	26.6 (22.4, 33.8)	28.5 (23.0, 34.4)	19.7 (14.9, 23.0)	<0.001
15–26 weeks	31.7 (23.9, 39.6)	33.9 (27.1, 41.4)	20.4 (17.7, 24.2)	<0.001
23–31 weeks	29.9 (23.4, 38.3)	31.0 (25.4, 39.6)	19.1 (13.7, 23.9)	<0.001
33–39 weeks	29.7 (23.1, 37.6)	31.8 (24.3, 38.3)	20.5 (13.0, 28.2)	<0.001
Free leptin indexb
10–14 weeks	1.2 (0.7, 2.2)	1.0 (0.6, 1.8)	3.5 (2.4, 4.6)	<0.001
15–26 weeks	1.2 (0.7, 2.1)	1.0 (0.7, 1.6)	3.8 (2.9, 4.4)	<0.001
23–31 weeks	1.3 (0.8, 2.3)	1.2 (0.7, 2.1)	4.1 (2.6, 6.7)	<0.001
33–39 weeks	1.4 (0.7, 2.4)	1.1 (0.6, 2.3)	3.4 (2.2, 5.8)	<0.001
HMW-adiponectin, μg/ml
10–14 weeks	4.1 (2.9, 6.5)	4.7 (3.2, 7.2)	2.5 (1.8, 3.5)	<0.001
15–26 weeks	3.8 (2.7, 5.6)	4.1 (3.0, 6.2)	2.4 (1.8, 3.5)	<0.001
23–31 weeks	3.2 (2.3, 4.9)	3.5 (2.3, 5.2)	2.3 (1.8, 3)	<0.001
33–39 weeks	2.9 (1.9, 4.5)	3.0 (2.1, 4.8)	2.2 (1.0, 3.8)	<0.001
Total Adiponectin, μg/ml
10–14 weeks	7.1 (4.8, 10.6)	7.9 (5.1, 11.3)	4.5 (3.8, 6.5)	<0.001
15–26 weeks	6.7 (4.7, 9.4)	7.2 (5, 9.8)	4.6 (3.5, 6.3)	<0.001
23–31 weeks	5.8 (4.1, 7.9)	5.8 (4.2, 8.5)	5.1 (3.3, 5.8)	0.003
33–39 weeks	5.1 (3.5, 7.5)	5.3 (3.6, 7.9)	4.1 (2.5, 6.2)	0.03

Abbreviations: BMI, body mass index; HMW, high molecular weight; IQR, interquartile range; sOB-R, soluble leptin receptor.

^aP-value represents the difference between the median level in women with a pre-pregnancy BMI <30.0 kg/m² and ≥ 30.0 kg/m²

^bFree leptin index calculated as Leptin (ng/ml)/sOB-R (ng/ml).