Figure 3.

Comparison of in vivo [99] and CFD [98] predictions of deposition fraction (DF) in different regions of the airways for the Respimat inhaler with a fenoterol formulation. Reasonable agreement is achieved at the level of available in vivo data resolution including the mouth-throat (MT), central (C), and intermediate + peripheral (I+P) airways with one SIP unit considered in each lung lobe. Diseased airways or more refined deposition predictions will require additional SIP pathways.

Reproduced from Tian et al. [98] with permission of Springer Nature.

EXP: in vivo experimental results; CFD: computational fluid dynamics predictions