Figure 7.

Late molecular changes following inducible cardiomyocyte-specific deletion of ROCK2. A) Representative image of Western blot of ROCK1, ROCK2, p-MLC, MLC, p-FAK, FAK, smooth-muscle α-actin (SM actin), LC3, p-mTOR, and mTOR in the ventricular homogenates from 7-, 9-, or 12-mo-old MCM/ROCK2^fl/fl mice collected 1, 3, or 6 mo after the TAM or oil injection received at 6 mo of age or from 12-mo-old MCM/ROCK1^fl/fl mice collected 6 mo after the TAM or oil injection. B) Quantitative analysis of immunoreactive bands of p-MLC and MLC, p-FAK and FAK, SM actin, LC3-II, and p-mTOR and mTOR; n = 4–6 in each group. *P < 0.05 vs. oil-injected group of same genotype.