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Diagram showing structural components and major players involved in the Tsg101-mediated endosomal recycling of IGF-1R. Tsg101 interacts with and enhances the function of FIP3 at the ERC. Increased activity of the ERC promotes translocation of IGF-1R to the plasma membrane, which in turn augments IGF-IR and Akt signaling in cardiac myocytes, leading to physiologic cardiac hypertrophy.
