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. 2019 Mar 18;33(6):7451–7466. doi: 10.1096/fj.201802338RR

Figure 3.

Figure 3

Elevation of Tsg101 in the heart augments endosomal recycling of IGF-1R. A, B) Representative Western blots (A) and quantification results (B) of protein levels of Rab5a, Rab4a, Rab7, Rab11a, and FIP3 in Tsg101-TG hearts compared with WTs. C, D) GAPDH was used as loading control. Representative Western blots (C) and quantification results (D) showing increased levels of total and plasma membrane IGF-1R and Akt phosphorylation in Tsg101-TG hearts compared with WTs. Total Akt was loading control for Akt phosphorylation, and Na/K-ATPase was loading control for plasma membrane protein. D, transgenic line D; G, transgenic line G; n = 6. *P < 0.05 vs. WTs.