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The C26 tumors cause significant metabolic derangements. A) Assessment of PDH and SDH enzymatic activities in gastrocnemius muscle of control and C26 tumor–bearing mice (C26). Data are expressed as mU/ml for PDH or mU/μl for SDH. B) Representative Western blotting for PDK4 in whole-muscle protein extracts from mice bearing the C26 tumor (n = 8). Tubulin was used as loading control. Data (means ± sd) are expressed as fold change vs. control. *P < 0.05, **P < 0.01.
