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. 2019 Mar 20;33(6):7778–7790. doi: 10.1096/fj.201802799R

Figure 4.

Figure 4

In vivo WY-14643 administration induces a cachectic phenotype. A–C) Cumulative food intake (A), body weight curves (B) and body weight change (i.e., body weight at time of euthanization vs. initial body weight) (C) in mice fed a diet enriched with 0.1% WY-14643. D) Body composition assessment in mice fed WY-14643 was performed by means of EchoMRI. Data are expressed in grams of fat or lean tissue at time of euthanization. E) Representative image of hindlimb musculature in mice fed a control or WY-14643–enriched diet. F) Skeletal muscle weights (tibialis anterior, gastrocnemius, and quadriceps) in mice fed control or WY-14643 diets. Weights were normalized to the initial body weight (IBW) and expressed as weight/100 mg IBW; n = 8. Data are means ± sd. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control.