TABLE 4.

Effect of gestational hypoxia compared to normoxia on gene expression in the ovary of adult female rats

Gene	Expression level		Significance level
	Normoxia	Hypoxia
Pot1	508 ± 91	382 ± 37	NS
Chk1	269 ± 62	222 ± 36	NS
Chk2	713 ± 94	660 ± 53	NS
Cdk4	7928 ± 2430	9761 ± 1035	NS
Cdk6	382 ± 76	354 ± 42	NS
P53	10,796 ± 2216	18,816 ± 1775	0.01**
P21	1892 ± 350	4367 ± 1086	0.08
P16ink	344 ± 79	592 ± 138	0.09
Hif1a	7267 ± 3940	23,130 ± 4682	0.02*
Nfkβ	7288 ± 1181	6429 ± 776	NS
Nox2	7716 ± 2815	10,145 ± 2142	NS
Xo	9012 ± 1970	5981 ± 856	NS
Gp91phox	10,489 ± 1853	15,066 ± 1715	0.05*
P22phox	356 ± 66	892 ± 199	0.03*
P47phox	1440 ± 224	1592 ± 221	NS
P67phox	134 ± 23	169 ± 43	NS
Nrf2	20,489 ± 3662	21,479 ± 1582	NS
Hmox1	2273 ± 284	2311 ± 222	NS
Gpx1	77,136 ± 14,644	82,485 ± 15,296	NS
Mnsod	11,513 ± 2248	12,716 ± 2207	NS
CuZnsod	31,951 ± 6327	89,260 ± 12,321	<0.001***
Ecsod	31,328 ± 5823	38,331 ± 3371	NS
Catalase	8898 ± 1169	8448 ± 1681	NS
Alox12	196 ± 40	303 ± 48	NS
Alox15	605 ± 100	479 ± 93	NS
Ppia	30,565 ± 5526	32,628 ± 4212	NS

All reported P values have been adjusted to take account of multiple hypothesis testing. Nfkβ, nuclear factor κ-β DNA binding subunit; Nox2, NADPH oxidase 2; NS, not significant; P47phox, neutrophil cytosolic factor 1. *P < 0.05, **P < 0.01, ***P < 0.001.