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. 2019 Mar 11;46(3):211–222. doi: 10.1007/s10928-018-9614-9

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© Pfizer 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Prediction- and variability-corrected visual predictive check in a patients with ALL and b patients with NHL. The red lines show median (solid) and the 5th and 95th percentiles (dash) of the observed concentrations. The black lines show median (solid) and the 5th and 95th percentiles (dash) of the simulated concentrations, and shaded regions show the 95% CIs on quantities obtained by simulations (N = 1000)