Fig. 3.
Overall survival for the validation cohorts and impact of corticosteroid intake. Kaplan–Meier analysis of overall survival according to basal neutrophil in a series of 61 glioblastoma patients treated at recurrence with bevacizumab alone or with chemotherapy (a) and in a series of 26 glioblastoma patients treated at recurrence with nitrosoureas (b). c Impact of corticosteroid intake on neutrophil count in the series of 61 patients. The bottom of the box-and-whisker plot graph shows the 25th percentile of the variable, the line within the box indicates the median and the top of the box shows the 75th percentile. The ends of the whiskers are at 25th percentile − (1.5 × interquartile range) and 75th percentile + (1.5 × interquartile range). Outliers are indicated by small circles. **** indicates the p value of the neutrophil counts of patients taking corticosteroids versus those not taking corticosteroids (p = 1.3 × 10−7, calculated by t test). Kaplan–Meier analysis of overall survival according to basal neutrophil count in patients without corticosteroids (c) or with corticosteroids (d) and receiving a bevacizumab containing regimen