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. 2019 Feb 18;46(3):223–240. doi: 10.1007/s10928-019-09622-x

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Schematic presentation of the two studies incorporated into the analysis. Upper row: three LPS challenge doses (3, 30 and 300 µg·kg⁻¹ of LPS) were given in Study 1 and the TNF_α-response was measured. No time courses are available for LPS. Bottom row: the middle challenge dose (30 µg·kg⁻¹ of LPS) was selected for three groups of rats that received 0.3, 3 and 30 mg·kg⁻¹ of test-compound A in Study 2