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. 2019 Feb 18;46(3):223–240. doi: 10.1007/s10928-019-09622-x

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 12 — Upper row: Impact of different LPS doses (3, 30, 300 µg·kg⁻¹) on TNF_α-response given with (solid lines) and without (dashed line) 3 mg·kg⁻¹ of test compound. Bottom row: Impact of a fixed LPS dose (30 μg·kg⁻¹) on TNF_α-response with (solid lines) and without (dashed lines) changing test compound doses (0.03, 0.3 and 3.0 mg·kg⁻¹). The red vertical dashed lines show the peak-time locations (Color figure online)