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. 2019 Feb 18;46(3):223–240. doi: 10.1007/s10928-019-09622-x

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Left: TNF_α-response time courses at increasing intravenous LPS challenge (3, 30 and 300 μg·kg⁻¹ LPS, shown as dotted, dashed and solid lines, respectively) in Sprague–Dawley rats from Study 1. The blue horizontal double arrow represents the initial time delay in onset of response, and the red vertical double arrow, the 20–80 range in TNF_α peak-response of the 30 μg·kg⁻¹ LPS challenge. Right: Semi-logarithmic plot of the same TNF_α-response time courses (Color figure online)