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. 2019 Feb 18;46(3):223–240. doi: 10.1007/s10928-019-09622-x

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 8 — Observed concentrations (red dots) and predicted response time courses (solid lines) of TNF_α-response for all subjects in Study 1. LPS challenge was 3 µg·kg⁻¹ (upper), 30 µg·kg⁻¹ (middle) and 300 µg·kg⁻¹ (lower) (Color figure online)