Table 3.

Final pharmacodynamic model estimates, their CV% and IIV and IIV CV% as well as resulting half-life

Parameter	Units	Final estimate	CV%	IIV%	IIV CV%	Half-life (min)
k LPS	h−1	8.36	29	30.4	19	5
k s	h−1	3.28	8.1	–	–	13
K m,LPS	µg·kg−1	0.0789	19	–	–
S max	ng·L−1·h−1	6·105	12	–	–
SC 50	–	0.469	14	9.0	42
γ	–	3.79	2.5	–	–
k out	h−1	5.65	30	14.8	34	7
k t	h−1	0.419	37	–	–	100