Fig. 1.

RN ablation impairs reaching and grasping, sparing locomotion. a Experimental design. b Neurotrace staining and lesion protocol validation and quantification t(3) = 8.36, P = 0.0036, n = 4 mice (Scale bar, 500 µm). c Number, d length, e speed and f duration of bouts during locomotion in the OFT (n = 6 mice). g Example track plots and bout decomposition. h Failure for each limb in the EGT, 2WRM-ANOVA F(2,40) = 36.21, P < 0.0001 (HL: hindlimb, FL: forelimb, r: right, l: left). i Completion time, 2WRM-ANOVA F(2,40) = 23.81, P < 0.0001. j Weight loss stabilization at 85% body weight during the food restriction period. k Learning curve as pellets consumed in the SPRT. l Distribution of success and failure across the 3-time points. m Failure rate, 1WRM-ANOVA F(1.3,6.5) = 17.83, P = 0.0035. n Completion time, 1WRM-ANOVA F(1.2,5.9) = 8.43, P = 0.0251. o Number of attempts, 1WRM-ANOVA F(1.6,7.8) = 8.79, P = 0.0127. All data are reported as mean and SEM. Pre-lesion performance are depicted in orange (Pre), performance 48 h after lesion are shown in green and performance a week after lesion (1 w) are displayed in purple