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. 2019 May 21;9:7643. doi: 10.1038/s41598-019-44089-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DCK expression in archival tissue does not correlate with outcome in patients treated with NUC-1031. (A) Nucleus and cytoplasm DCK histoscores in tissue from patients who achieved stable disease for less than six months, or progressive disease developed within that time (group 1, n = 22), or who achieved stable disease for six months or more (group 2, n = 17). Tissues were immunostained for DCK and scanned images were quantified using QuPath and histoscores compared between groups (DCK nucleus p-value = 0.2102; DCK cytoplasm p-value = 0.1461; Mann-Whitney test). (B) Lung cancer from a partial responder, who had not been previously treated with gemcitabine and survived for 10 months while receiving NUC-1031, displayed high DCK expression. QuPath segmentation of tumour (red) and stroma (green) (left panel) or unsegmented image (right panel). Blue arrow, DCK nuclear expression. Red arrow, DCK cytoplasmic expression. (C) Pancreatic cancer from a patient who had relapsed on prior gemcitabine treatment but achieved a 30% reduction in tumour volume (partial response) within 3 cycles of NUC-1031 treatment, displayed low DCK expression. QuPath segmentation of tumour (red) and stroma (green) (left panel) or unsegmented image (right panel). Blue arrow, DCK negative cancer cell. Red arrow, DCK negative immune cell.