Table 1.

Clinical and pathological features of MM patients analyzed

Sample (MM PCs)	%intramedullary PCs	Paraprotein type	ISS	ISS-R	High LDH	Karyotype	C	R	A	B
(A)
MM1	80%	IgG/κ	III	III	Y	t(4;14), gain 1q, hypodiploid	N	N	Y	N
MM1.2	75%	IgG/κ			Y	t(4;14), gain 1q	N	N	Y	Y
MM2	70%	IgG/κ+κ	III	II	N	Normal	Y	Y	Y	Y
MM3	100%	IgG/κ	II	II	N	Normal	N	N	Y	Y
MM4	30%	IgG/λ	III	II	N	Normal	N	N	Y	N
MM5	100%	κ	ND	ND	N	Normal	N	N	Y	Y
MM6	70%	IgG/λ	II	II	N	Hyperdiploid	N	N	Y	Y
MM7	70%	IgA/κ	II	II	N	Hyperdiploid	N	N	Y	N
MM8	60-70%	IgG/λ	III	III	Y	del17p, gain1q	N	Y	Y	N
MM9	95%	IgG/κ	I	I	N	t(11;14)	N	N	N	Y
(B)
BMSC1	50%	IgG/λ	I	I	N	Hyperdiploid	Y	N	Y	Y
BMSC2	100%	IgA/κ	III	II	N	del1p, hypodiploid	Y	Y	Y	Y
BMSC3	30%	κ	NA	NA	ND	gain1q
BMSC4	45%	IgG/κ	II	II	N	Hyperdiploid	N	N	N	Y
BMSC5	70%	IgA/λ	I	I	N	Hyperdiploid	N	N	Y	Y

MM plasma cells (A) and MM BMSC (B) were isolated from the bone marrow of patients. Clinical staging was performed according to the International Staging System (ISS; albumin levels ≤ or > 35 g/L; β2-microglobulin levels ≤ or > 3.5 mg/L) and to the International Staging System-Revisited in 2015 (ISS-R, in addition to the ISS criteria, considered the presence of high level of LDH and the presence of chromosomal abnormalities). The presence of high lactate dehydrogenase LDH was evaluated. All features are reported as data at diagnosis

PC plasma cell, BMSC bone marrow stromal cell, ISS International Staging System, ISS-R International Staging System-Revised, LDH lactate dehydrogenase, C calcium elevated, R renal failure, A anemia, B bone disease, Y yes/present, N no/absent, NA not available, ND not determined