Table 2.
Characteristics of the 36 peptides selected for the prognostic model and hazard ratios measured in the entire cohort (n = 98).
| Protein Name | Protein Symbol | Mass [Da] | CE time [min] | Hazard ratio |
|---|---|---|---|---|
| Collagen alpha-3(IV) chain | COL4A3 | 3349.54 | 30.97 | HR: 8.75 (95% CI, 1.3–59.04), p = 0.026 |
| — | — | 4846.20 | 26.65 | HR: 6.69 (95% CI, 1.95–22.99), p = 0.003 |
| Peptidoglycan recognition protein 1 | PGLYRP1 | 2187.99 | 27.08 | HR: 4.86 (95% CI, 1.47–16.02), p = 0.009 |
| Collagen alpha-1(I) chain | COL1A1 | 2488.11 | 27.95 | HR: 4.26 (95% CI, 1.23–14.72), p = 0.022 |
| Collagen alpha-1(I) chain | COL1A1 | 1522.68 | 22.23 | HR: 3.84 (95% CI, 0.76–19.45), p = 0.104 |
| Collagen alpha-1(I) chain | COL1A1 | 2103.96 | 33.08 | HR: 3.74 (95% CI, 0.59–23.87), p = 0.163 |
| Polymeric immunoglobulin receptor | PIGR | 3556.62 | 23.96 | HR: 3.64 (95% CI, 1.29–10.23), p = 0.014 |
| Collagen alpha-4(IV) chain | COL4A4 | 2093.93 | 33.71 | HR: 3.53 (95% CI, 1.3–9.56), p = 0.013 |
| Collagen alpha-1(III) chain | COL3A1 | 2898.31 | 29.25 | HR: 3.15 (95% CI, 0.6–16.58), p = 0.175 |
| Collagen alpha-1(XIV) chain | COL14A1 | 3546.67 | 26.15 | HR: 3.15 (95% CI, 0.99–10.02), p = 0.051 |
| Forkhead box protein D2 | FOXD2 | 3057.39 | 29.96 | HR: 3.11 (95% CI, 1.18–8.16), p = 0.021 |
| Collagen alpha-1(VI) chain | COL6A1 | 3136.39 | 24.55 | HR: 2.65 (95% CI, 0.82–8.6), p = 0.105 |
| Collagen alpha-1(III) chain | COL3A1 | 2564.15 | 23.00 | HR: 2.4 (95% CI, 0.99–5.84), p = 0.054 |
| Collagen alpha-1(V) chain | COL5A1 | 3385.59 | 25.54 | HR: 2.37 (95% CI, 0.79–7.08), p = 0.123 |
| Collagen alpha-1(III) chain | COL3A1 | 2323.05 | 22.39 | HR: 2.34 (95% CI, 0.8–6.81), p = 0.12 |
| Collagen alpha-1(V) chain | COL5A1 | 3722.78 | 21.94 | HR: 2.32 (95% CI, 0.84–6.44), p = 0.106 |
| Fibrinogen alpha chain | FGA | 3314.48 | 20.21 | HR: 2.22 (95% CI, 1.09–4.51), p = 0.028 |
| — | — | 9866.38 | 20.83 | HR: 2.21 (95% CI, 1.04–4.68), p = 0.039 |
| Collagen alpha-1(III) chain | COL3A1 | 2007.94 | 22.12 | HR: 2.15 (95% CI, 0.84–5.48), p = 0.11 |
| Ankyrin repeat domain-containing protein 36C | ANKRD36C | 5574.25 | 23.16 | HR: 2.12 (95% CI, 0.85–5.27), p = 0.105 |
| — | — | 8175.89 | 19.47 | HR: 1.88 (95% CI, 0.75–4.71), p = 0.176 |
| Collagen alpha-1(I) chain | COL1A1 | 2030.92 | 32.65 | HR: 1.79 (95% CI, 0.44–7.2), p = 0.413 |
| Collagen alpha-1(I) chain | COL1A1 | 2236.98 | 27.14 | HR: 1.6 (95% CI, 0.66–3.91), p = 0.298 |
| Collagen alpha-1(VIII) chain | COL8A1 | 3292.54 | 39.27 | HR: 0.89 (95% CI, 0.37–2.16), p = 0.8 |
| Nebulin | NEB | 1135.49 | 27.79 | HR: 0.84 (95% CI, 0.34–2.08), p = 0.714 |
| Collagen alpha-1(I) chain | COL1A1 | 2170.97 | 27.53 | HR: 0.76 (95% CI, 0.32–1.8), p = 0.533 |
| Collagen alpha-1(I) chain | COL1A1 | 2319.04 | 33.85 | HR: 0.64 (95% CI, 0.27–1.52), p = 0.31 |
| Collagen alpha-2(IV) chain | COL4A2 | 2264.94 | 43.13 | HR: 0.62 (95% CI, 0.37–1.03), p = 0.063 |
| Collagen alpha-1(XI) chain | COL11A1 | 4169.93 | 33.60 | HR: 0.56 (95% CI, 0.28–1.11), p = 0.096 |
| Collagen alpha-1(I) chain | COL1A1 | 3432.59 | 31.95 | HR: 0.53 (95% CI, 0.21–1.33), p = 0.179 |
| Collagen alpha-1(XV) chain | COL15A1 | 1942.83 | 31.05 | HR: 0.42 (95% CI, 0.11–1.55), p = 0.193 |
| Collagen alpha-1(III) chain | COL3A1 | 1834.84 | 24.21 | HR: 0.37 (95% CI, 0.15–0.91), p = 0.03 |
| Collagen alpha-1(II) chain | COL2A1 | 1179.51 | 27.78 | HR: 0.36 (95% CI, 0.12–1.09), p = 0.07 |
| CD99 antigen | CD99 | 1954.97 | 25.45 | HR: 0.27 (95% CI, 0.1–0.71), p = 0.008 |
| Collagen alpha-1(I) chain | COL1A1 | 1795.79 | 24.93 | HR: 0.26 (95% CI, 0.08–0.88), p = 0.03 |
| Collagen alpha-1(III) chain | COL3A1 | 1396.62 | 26.63 | HR: 0.19 (95% CI, 0.03–1.27), p = 0.088 |