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. 2019 Jan 24;12(1):3–16. doi: 10.1007/s12307-018-00219-5

Fig. 1.

Fig. 1

Major microenvironment influencing factors. A schematic overview of the 4 major factors influencing the tumor microenvironment in post-transplant lymphoproliferative disorders. The Epstein-Barr virus has multiple para- and autocrine effects; chronic antigen stimulation leads to T-cell exhaustion; iatrogenic immunosuppression causes T-cell depletion and possible interactions between host derived and (co-)transplanted donor immune cells need to be further investigated