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. 2019 May 21;9:7666. doi: 10.1038/s41598-019-43948-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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OA development in Col2a1-Cre;Runx1^fl/fl and Runx1^fl/fl mice. (a) Gross appearance of Col2a1-Cre;Runx1^fl/fl and Runx1^fl/fl littermates at 8 weeks of age. Scale bars, 10 mm. (b) Total body weight of Col2a1-Cre;Runx1^fl/fl and Runx1^fl/fl littermates at 8 or 16 weeks of age. Data are expressed as means (symbols) ± SD (error bars) of 15 mice per group. (c) Runx1 immunofluorescence in normal knee cartilage of Col2a1-Cre;Runx1^fl/fl and Runx1^fl/fl littermates at 16 weeks of age. Scale bars, 50 μm. (d) Safranin O staining of knee joints 8 weeks after OA surgery in Col2a1-Cre;Runx1^fl/fl and Runx1^fl/fl littermates. Scale bars, 200 μm. (e) Quantification of OA development by Osteoarthritis Research Society International (OARSI) grading system and osteophyte formation score. Data are expressed as means ± SD of 15 mice per group. *P < 0.05 vs. Runx1^fl/fl. (f) Quantification of OA development by Osteoarthritis Research Society International (OARSI) grading system and osteophyte formation score in normal knee cartilage of Col2a1-Cre;Runx1^fl/fl and Runx1^fl/fl littermates at 16 weeks of age. Data are expressed as means ± SD of 6 mice per group.