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. 2019 May 21;9:7666. doi: 10.1038/s41598-019-43948-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Altered marker expression by Runx1. (a) Safranin O staining and immunohistochemistry with antibodies to marker proteins in articular cartilage of 16-week-old Col2a1-Cre;Runx1^fl/fl and Runx1^fl/fl littermates under physiological conditions. Inset boxes in Safranin O staining indicate regions shown in enlarged safranin O and immunostaining images. Scale bars, 50 μm. (b) mRNA levels of marker genes in Runx1^fl/fl primary articular chondrocytes adenovirally transduced (Ax) with GFP, Runx1, or Cre after 5 days of culture. *P < 0.01 versus Ax-GFP. Data are expressed as mean ± SD of six samples per group.