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. 2019 May 21;9:7665. doi: 10.1038/s41598-019-43492-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Montpellier cohort: NanoCRCA assay, its comparison with other platforms and the CMS classifier; and Singapore FF cohort: NanoCRCA assay. (a) A summary of the Montpellier cohort showing patient characteristics, sample size and available microarray data. (b) Heatmap showing the expression of the 38-gene-panel in the Montpellier cohort as measured using NanoCRCA assay (n = 17). From top to bottom, the upper bars indicate the CMS, CRCA-786 and CRCA-38 subtypes as determined by microarray profiles, and the NanoCRCA subtypes as determined by nCounter profiles. The right-hand vertical bar indicates the subtype association of each gene. The percentage of samples falling into each CMS and CRCA subtype is shown on the right. (c,d) Comparisons between NanoCRCA and microarray-based classifications CRCA-38, CRCA-786 and CMS showing c) percent concordance to NanoCRCA and d) statistical significance (Fisher’s exact test) in the Montpellier cohort. (e) A summary of the Singapore FF cohort showing patient characteristics and sample size. (f) Heatmap showing the expression of the 38-gene panel in the Singapore FF cohort as measured using NanoCRCA assay (n = 145). The subtypes as assigned using the NanoCRCA assay are shown on the top bar. The right-hand vertical bar indicates the subtype association of each gene. Subtype colours are as in b).