Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 May 15;10:1095. doi: 10.3389/fimmu.2019.01095

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Zhang, Fu, Wang, Guan, Zhu, Guo, Zheng and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

IL-10 induced the expression of miR-146b during SFTSV-induced macrophage differentiation. (A, B)The expression of miR-146a (A) or b (B) of THP-1 cells pretreated or not pretreated for 5 μM of the JAK/STAT inhibitor AG-490 or 10 μg/mL anti-IL-10 receptor (-αIL-10R) mAb and then infected with SFTSV at an MOI of 1 by quantitative real-time PCR. (C,D) Real-time PCR analysis of IL-13 (C) and IL-4 (D) mRNA expression in THP-1 cells infected with SFTSV. (E,F) Expression levels of IL-10 (E) and IL-4 (F) were measured using ELISA in SFTSV infected patient sera. (G) Western blot of STAT3 protein expression in SFTSV-infected THP-1 cells at various time points. Data are shown as means with ±SEM of three independent experiments (^*P < 0.05, ^**P < 0.01, ^***P < 0.001).