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. 2019 May 15;10:1095. doi: 10.3389/fimmu.2019.01095

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Copyright © 2019 Zhang, Fu, Wang, Guan, Zhu, Guo, Zheng and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SFTSV induced macrophage differentiation in vivo. (A). Flow-cytometry profiling of mouse splenic macrophages subsets after SFTSV infection. Macrophages were gated CD11b⁺ and F4/80⁺, M1 macrophages were gated CD11c⁺, and M2 macrophages were gated CD206⁺. (B,C) The expression level of IL-10 (B) and IL-4 (C) were determined by ELISA in mouse serum that infected with SFTSV. (D,E)The expression of miR-146a (D) and miR-146b (E) within sorted mouse splenic macrophages in each group (n = 3). Data in all panels are shown as mean ± SEM (^*P < 0.05, ^**P < 0.01, ^***P < 0.001).