Table 2.

Psychotropic drugs detected in the Hennops and Jukskei Rivers, together with their registration status with the South African Health Products Regulatory Authority (SAHPRA, as of 30 October 2018) and scheduling

Type	Emerging pollutant	*Reg	**Scheduling	Hennops ds	N14	Diepsloot	Farmall	Sunninghill	Midrand	Buccleuch
ANTD	Bupropion	Y	S5	X	√	X	X	X	X	X
	Citalopram	Y	S5	√	√	X	√	√	√	√
	Fluoxetine	Y	S5	√	√	X	X	X	X	X
	Maprotiline	Y	S5	√	√	X	X	X	X	X
	Moclobemide	Y	S5	X	√	X	X	X	X	X
	Norcitalopram	N	N/A	X	X	X	√	X	X	X
	Sertraline	Y	S5	√	√	X	X	X	X	X
	Venlafaxine	Y	S5	√	√	X	√	√	√	√
CANNB	Tetrahydrocannabinol	N	N/A	X	X	X	X	X	X	√
OPAN	Dihydrocodeine	Y	S6	√	√	X	X	X	X	X
	Hydrocodone	N	N/A	√	√	√	√	√	√	√
	Hydromorphone	Y	S6	√	√	√	X	X	√	√
	Ketobemidone	N	N/A	X	X	√	X	√	X	X
	Meptazinol	N	N/A	X	X	X	X	√	X	X
	Morphine	Y	S6	√	√	√	X	X	√	√
	Oxycodone	Y	S6	√	√	X	√	√	X	X
	Oxymorphone	N	N/A	X	X	X	√	X	X	X
	Pethidine	Y	S6	X	X	X	√	X	X	X
	Tramadol	Y	S5	√	√	√	√	√	√	√
PSYSTIM	5-Methoxytryptamine	N	N/A	√	√	X	X	X	X	X
	5-MeOT	N	N/A	X	X	X	X	√	X	X
	6-APB	N	N/A	X	√	X	X	X	X	X
	Amphetamine	N	N/A	X	√	X	√	X	X	X
	AMT	N	N/A	X	√	X	X	X	X	X
	bk-MDDMA	N	N/A	X	√	X	X	√	X	√
	Cathinone	N	N/A	X	X	X	X	X	X	√
	Ethylone	N	N/A	X	√	X	X	X	X	X
	MDA	N	N/A	X	X	√	X	X	X	X
	MDAI	N	N/A	X	X	X	X	X	X	√
	MDEA	N	N/A	X	X	X	X	√	√	√
	MDMA	N	N/A	X	X	X	X	√	X	X
	Methamphetamine	N	N/A	X	√	√	X	√	√	√
	Methcathinone	N	N/A	√	X	X	X	X	√	√
	Phentermine	Y	S5	√	√	X	X	√	√	√
	Pyrovalerone	N	N/A	X	X	X	X	√	X	X
	Sulpiride	Y	S5	X	X	X	X	√	√	√
EPD	Carbamazepine	Y	S3 and S5	√	√	√	√	√	√	√
	Gabapentin	Y	S3	√	X	X	√	X	X	X
	Lamotrigine	Y	S3	√	√	√	√	√	√	√
	Levetiracetam	Y	S3	√	√	X	√	X	√	√
	Nordiazepam	N	N/A	√	√	X	X	X	X	X
	Oxcarbazepine	Y	S3	√	√	√	√	√	X	√
	Phenytoin	Y	S3	X	X	√	√	X	X	X
	Pregabalin	Y	S5	√	X	X	X	X	X	X
	Primidone	Y	S3	X	√	√	√	X	X	X
SED/T	Clobazam	Y	S5	√	√	X	X	X	X	X
	Meprobamate	Y	S5	√	√	√	√	√	√	√
	Methaqualone	N	N/A	√	√	√	√	√	√	√
	Oxazepam	Y	S5	√	√	X	√	√	√	√
	Promazine	N	N/A	√	X	X	X	X	X	X
	Sulpiride	Y	S5	√	√	X	X	X	X	X
	Temazepam	Y	S5	√	√	X	X	X	√	X
Total number detected				28	33	14	19	21	18	22

*Registration with the South African Health Products Regulatory Authority (SAHPRA, as of 30 October 2018)

**See Table S3 for schedule description

5-MeOT 6-(2-aminopropyl)benzofuran), 6-APB alpha-pyrrolidinopentiophenone, AMT alpha-methyltryptamine, MDA methylenedioxyamphetamine, bk-MDDMA dimethylone, MDAI 5,6-methylenedioxy-2-aminoindane, MDEA 3,4-methylenedioxy-N-ethylamphetamine, MDMA 3,4-methylenedioxy-methamphetamine, ANTD antidepressant, CANNB cannabis, OPAN opioid analgesic, PSYSTIM psychoactive stimulant, EPD epilepsy and anticonvulsant drug, SED/T sedative/tranquiliser drug