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. 2019 Jun;7(6):497–508. doi: 10.1016/S2213-2600(18)30508-3

Table.

Hazard ratios in study cohorts with idiopathic pulmonary fibrosis for GAP index and monocytes

Hazard ratio 95% CI p value
COMET (n=36)
GAP index 1·42 0·77–2·63 0·26
Monocytes 2·65 0·95–7·34 0·060
Monocytes (age and sex corrected) 2·46 0·86–6·98 0·092
Monocytes (FVC-corrected) 2·69 0·97–7·45 0·057
Monocytes (GAP-corrected) 2·64 0·95–7·33 0·062
Stanford (n=130)
GAP index 1·73 1·34–2·25 <0·0001
Monocytes 2·83 1·17–6·81 0·026
Monocytes (age and sex corrected) 2·30 0·94–5·63 0·067
Monocytes (FVC-corrected) 2·43 1·00–5·91 0·049
Monocytes (GAP-corrected) 1·87 0·76–4·61 0·17
Vanderbilt (n=1607)
Monocytes 1·46 1·17–1·82 0·00094
Monocytes (age and sex corrected) 1·52 1·21–1·89 <0·0001
Optum (n=5722)
Monocytes 1·96 1·50–2·56 <0·0001
Monocytes (age and sex corrected) 1·74 1·33–2·27 <0·0001
Northwestern (n=365)
GAP index 1·65 1·35–2·02 <0·0001
Monocytes 2·25 1·01–5·04 0·049
Monocytes (age and sex corrected) 2·06 0·91–4·69 0·082
Monocytes (FVC-corrected) 2·39 1·06–5·38 0·035
Monocytes (GAP-corrected) 1·90 0·83–4·36 0·13

Data are shown with and without correction for age, sex, predicted forced vital capacity (FVC), and GAP (gender, age, and physiology index).