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. 2019 May 21;10(3):e00190-19. doi: 10.1128/mBio.00190-19

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Copyright © 2019 Krishnamoorthy et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Genomic organization of mft genes in M. tuberculosis H37Rv and M. smegmatis mc²155. The schematic illustration (not drawn to scale) presents the gene names corresponding to the following mft ortholog locus numbers and functional annotations: mftA, Rv0691A/MSMEG_1421, precursor peptide; mftB, Rv0692/MSMEG_1422, MftA chaperone; mftC, Rv0693/MSMEG_1423, radical S-adenosylmethionine maturase; mftD, Rv0694/MSMEG_1424, flavin/heme dehydrogenase; mftE, Rv0695/MSMEG_1425, creatinine aminohydrolase family protein; mftF, Rv0696/MSMEG_1426, glycosyltransferase. mftB, mftC, mftD, mftE, and mftF are identified as essential for M. tuberculosis in vitro growth in cholesterol (20, 21).