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Distribution and relative abundance of signals for the top 50 OTUs in baseline samples from young (A), adolescent (B), adult (C), and aged (D) animals and readouts for each OTU/species and for samples collected at 2 weeks (0.5 months) and at 1 and 3 months postligation during initiation and progression of disease. The asterisks denote a significant difference from the baseline with disease (0.5, 1, and 3 months) at a P value of at least <0.05 using Z-score normalization.
