FIG 1.

Domain architecture of L. pneumophila effectors that bind PIs. The known domains of each effector that contains a PI-binding domain are shown. The domains presented are as follows: PI4P-M, PI4P-binding domain of SidM; PI4P-C, PI4P-binding domain of SidC; PI3P-BD, PI3P-binding domain; PI3/4P-BD, PI3P and PI4P-binding domain; deconjugation, a domain related to cysteine proteases, required for Atg8 deconjugation reaction; AMPylase, AMPylation of Rab1; GEF, GTP-GDP exchange factor for Rab1; GlyT, glycosyltransferase; SNL, N-terminal ubiquitin ligase domain; FIC, filamentation induced by cAMP, used by AnkX for phosphocholination of Rab1; Ank, ankyrin repeat; PTP, protein tyrosine phosphatase; Vps29 binding, domain that binds the Vps29 retromer subunit. Domains with the same name and different colors perform the same function but are not homologous.