Fig. 1.

High-glucose load impairs glucose tolerance in wild-type mice. Wild-type mice (n = 8) were administrated with high-glucose (10 and 20 mg/kg, respectively) or saline 0.9% solution. At 1 week, the blood was collected for analyzing the fasting blood glucose (A), plasma insulin levels (B), glucose tolerance curve (C), the area under the curve (D), insulinogenic index (ISI) of islet β-cell (E), and the homeostasis model assessment of insulin resistance (HOMA-IR) (F). Differences between the treatment group and the control group are presented in the figure (*p<0.05). The values are mean ± SEM.