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. 2019 May 17;12:3893–3903. doi: 10.2147/OTT.S199601

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© 2019 Yin et al.

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Curcumin reduced OXA chemoresistance in CRC by inhibiting TGF-β/Smad2/3 pathway in vivo. HCT116/OXA cells were subcutaneously implanted into nude mice. Mice were divided into four groups: vehicle group, OXA alone group, curcumin alone group and OXA plus curcumin group. (A) Tumor volume of xenograft was measured weekly. (B) The mice were sacrificed in 3 weeks, and the tumors were isolated (C) Quantification of tumor weights in each group. (D–G) The relative protein levels of p-Smad2, p-Smad3 and E-cadherin in tumor tissues were measured by Western blot. Each experiment was repeated three times. **P<0.01 compared to control group; ^##P<0.01, compared to OXA alone group.