Table 4.

Cox regression on association between pathologic stage after preoperative chemoradiotherapy (CRT) and survival outcomes

Variable	Univariable analysis		Multivariable analysis
	Hazard ratio (95% CI)	P-value	Hazard ratio (95% CI)	P-value
Overall survivala
Pathologic AJCC after preoperative CRT
Stage 0	1.00 (reference)	-	1.00 (reference)	-
Stage I	1.97 (0.83–4.67)	0.120	2.20 (0.93–5.23)	0.070
Stage II	3.62 (1.61–8.13)	0.002	3.75 (1.66–8.47)	0.001
Stage III	3.77 (3.08–14.87)	<0.001	6.97 (3.16–15.39)	<0.001
Pathologic T classification
ypT0	1.00 (reference)	-	1.00 (reference)	-
ypT1	1.14 (0.30–4.30)	0.850	1.32 (0.35–5.02)	0.690
ypT2	2.23 (1.00–4.97)	0.050	1.97 (0.88–4.43)	0.100
ypT3	4.78 (2.31–9.87)	<0.001	3.61 (1.69–7.70)	0.001
ypT4	3.03 (0.38–24.26)	0.300	1.98 (0.24–16.23)	0.520
Pathologic N classification
ypN0	1.00 (reference)	-	1.00 (reference)	-
ypN1	2.65 (1.79–3.94)	<0.001	1.86 (1.22–2.83)	0.004
ypN2	3.95 (2.21–7.06)	<0.001	3.10 (1.69–5.70)	<0.001
Disease-free survivalb
Pathologic AJCC after preoperative CRT
Stage 0	1.00 (reference)	-	1.00 (reference)	-
Stage I	2.24 (1.06–4.75)	0.040	2.33 (1.09–4.94)	0.030
Stage II	4.10 (2.01–8.35)	<0.001	4.05 (1.98–8.28)	<0.001
Stage III	7.45 (3.73–14.90)	<0.001	7.30 (3.63–14.67)	<0.001
Pathologic T classification
ypT0	1.00 (reference)	-	1.00 (reference)	-
ypT1	1.05 (0.33–3.35)	0.930	1.07 (0.34–3.40)	0.910
ypT2	2.21 (1.09–4.49)	0.030	2.01 (1.01–4.00)	0.050
ypT3	4.65 (2.43–8.89)	<0.001	3.52 (1.85–6.71)	<0.001
ypT4	8.71 (2.39–31.74)	0.001	5.72 (1.41–23.25)	0.020
Pathologic N classification
ypN0	1.00 (reference)	-	1.00 (reference)	-
ypN1	2.81 (2.01–3.93)	<0.001	2.01 (1.41–2.86)	<0.001
ypN2	3.26 (1.91–5.57)	<0.001	2.30 (1.31–4.04)	0.004

CI, confidence interval; AJCC, American Joint Committee on Cancer.

^aAdjusted for age, sex, American Society of Anesthesiologists physical status (ASA PS) classification, and operative name.

^bAdjusted for age, sex, ASA PS classification, operative name, and circumferential resection margin.