Table 2.
Descriptive analysis of pCR-related factors
| Variable | pCR (n = 29) | Non-pCR (n = 111) | P-value |
|---|---|---|---|
| Men | 19 (65.5) | 74 (66.7) | 1 |
| Age (yr) | 60.0 (55.0–68.0) | 65.0 (55.5–72.0) | 0.385 |
| CEA (ng/mL) | 2.4 (1.8–3.6) | 4.1 (2.2–7.4) | 0.008 |
| Pre-nCRT NLR | 1.8 (1.5–2.6) | 2.1 (1.7–3.0) | 0.042 |
| Post-nCRT NLR | 3.0 (2.5–3.8) | 3.7 (2.6–4.9) | 0.093 |
| Delay after RT (wk) | 7.0 (6.0–7.0) | 7.0 (6.0–7.0) | 0.641 |
| Tumor differentiation | 1 | ||
| Well/moderate | 28 (96.6) | 105 (94.6) | |
| Poor/mucinous | 1 (3.4) | 6 (5.4) | |
| cT4, yes | 0 (0) | 12 (10.8) | 0.139 |
| cN1, yes | 17 (58.6) | 96 (86.5) | 0.002 |
| Tumor location | 1 | ||
| RA | 4 (13.8) | 17 (15.3) | |
| RB | 25 (86.2) | 94 (84.7) | |
| Perforation, yes | 0 (0) | 3 (2.7) | 0.861 |
| Obstruction, yes | 1 (3.4) | 10 (9.0) | 0.546 |
| Pre-nCRT NLR > 2.77 | 4 (13.8) | 40 (36.0) | 0.038 |
| Post-nCRT NLR > 3.23 | 11 (37.9) | 69 (62.2) | 0.033 |
Values are presented as number (%) or median (interquartile range).
pCR, pathologic complete response; CEA, carcinoembryonic antigen; nCRT, neoadjuvant chemoradiation therapy; NLR, neutrophil to lymphocyte ratio; RT, radiotherapy; RA, above peritoneal reflection; RB, below peritoneal reflection.