Table 4.
Prognostic factors associated with recurrence-free survival using Cox regression analysis
| Variable | Univariate |
Multivariate |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Male | 2.314 | 0.875–6.117 | 0.091 | 2.301 | 0.707–7.482 | 0.166 |
| Age | 1.008 | 0.973–1.044 | 0.668 | |||
| ASA PS classifcation ≥ III | 0.906 | 0.341–2.409 | 0.843 | |||
| pre-nCRT NLR >2.66 | 2.750 | 1.304–5.799 | 0.008 | 2.300 | 1.061–4.985 | 0.035 |
| post-nCRT NLR >5.21 | 2.160 | 0.969–4.816 | 0.060 | |||
| CEA | 1.010 | 1.001–1.019 | 0.038 | 1.013 | 1.000–1.026 | 0.047 |
| cN1, yes | 1.201 | 0.457–3.162 | 0.710 | |||
| APR, yes | 2.066 | 0.967–4.413 | 0.061 | |||
| ypStage II/III | 3.937 | 1.595–9.720 | 0.003 | 2.761 | 0.978–7.792 | 0.055 |
| PD/MUC | 1.444 | 0.341–6.119 | 0.618 | |||
| Obstruction | 4.530 | 1.662–12.344 | 0.003 | 2.694 | 0.935–7.759 | 0.066 |
| N. of total retrieved LN | 0.987 | 0.932–1.046 | 0.669 | |||
| Lymphatic invasion, yes | 0.465 | 0.062–3.480 | 0.456 | |||
| Perineural invasion, yes | 4.812 | 2.227–10.398 | <0.001 | 2.592 | 1.063–6.320 | 0.036 |
| Vascular invasion, yes | 5.384 | 2.258–12.835 | <0.001 | |||
| pT4, yes | 9.063 | 2.663–30.849 | 0.003 | |||
| R1 resection | 4.425 | 1.646–11.896 | <0.001 | |||
| Adjuvant chemotherapy | 1.128 | 0.338–3.767 | 0.845 | |||
HR, hazard ratio; CI, confidence interval; ASA PS, American Society of Anesthesiologists physical status; CEA, carcinoembryonic antigen; APR, abdominoperineal resection; LN, lymph node.