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. 2019 May 15;10:457. doi: 10.3389/fgene.2019.00457

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Copyright © 2019 Li, Wang, Fu, Zhang, Cao, Wang, Zhang, Li, Chen, Li, Li, Jiang, Sun, Tian, Li and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network of EDNRB2-mediated regulation of chicken melanin synthesis. In melanocytes, the ET3 gene binds to EDNRB2 gene to activates the downstream signal transduction molecule PKC, and the activation of PKC activates the expression of many specific genes such as TYR, TYRP1, and DCT. The DCT gene can catalyze the transformation of dopamine into 5,6-dihydroxyindole carboxylic acid to accelerate the formation of melanin. ET3, endothelin 3; EDNRB, endothelin receptor B; EDNRB2, endothelin receptor B subtype 2; PKC, protein kinase C; MITF, melanogenesis associated transcription factor; TYR, tyrosinase; TYRP1, tyrosinase-related protein 1; DCT, dopachrome tautomerase.