Fig. 1.

Training data generation: (a) a training voxel with a dimension of $1\times 1\times t$, containing the concentration change along time $t$ and (b) a training patch with a dimension of $25\times 25\times t$, where $t=64$. The center of the patch (red) is the voxel of interest. A patch is associated with the outcome value (0 or 1) of the voxel of interest.